In a large mixing bowl, combine the ground beef with Cajun seasoning, garlic powder, onion powder, salt, and pepper. Mix gently to avoid overhandling, then form into four patties.

Preheat your grill to medium-high heat (around 375°F to 400°F) or heat a skillet with oil. Lightly oil the grill grate.

Cook the patties for 4–5 minutes on one side until grill marks form, then flip and cook an additional 3–4 minutes. Add cheese during the last minute to melt.

Butter and toast the cut sides of the burger buns on the grill until golden brown, about 1-2 minutes.

Assemble your burgers by spreading sauce on the bottom bun, topping with a cheesy patty, and adding your desired toppings.